On demand and long-term delivery of drugs are common requirements in many therapeutic applications, and it is not easy to solve using intelligent polymers that can be used for drug encapsulation.Creative BioMart provides a solution for researchers to solve such situations by using living materials that are self complementary and controlled by photogenetics. We transformed bacteria through metabolism and photogenetic engineering, so that they can secrete antibacterial and antitumor drugs or other components in a photoregulated manner. This solution allows the synthetic drug to diffuse and deliver to the surrounding medium in an amount regulated by the light dose. Using the focused beam, the synthesis and delivery sites of drugs can be defined freely.

Microencapsulated drugs are encapsulated in hydrogels to form viable therapeutic materials. Hydrogel provides a supportive environment for the survival of bacterial populations, and it is possible to minimize the safety of free release of bacteria into the body.

Application Scenarios of Technology

• Used in biocatalysis, probiotic food processing, biosensor and other industrial processes.
• To construct an active material that can release antibiotics for several days and kill Gram-positive bacteria in vitro.
• Used for cell culture and protein delivery to eukaryotic cells.
• Growth factors for inducing differentiation.

The modularity of the system allows for changes in each component including drugs, hydrogel matrices, microbes and genetic modules, thus providing wide adaptability for future applications in personalized therapy.

Available Services

Our optogenetic drug release platform allows E. coli to produce proteins under light irradiation. At present, our adaptive activation wavelengths include ultraviolet (382 nm), blue (470 nm), green (532 nm), red (650 nm), and near infrared (760 nm).

Our platform can be designed for metabolic production of drugs, including but not limited to purpurin, artemisinin, carbapenem, cinnamaldehyde, deoxyviolacein (dvio), etc

We provide customized platform construction services and protein expression services, including codon optimization, gene synthesis, protein expression and purification. If you need other services, such as protein refolding, label removal and endotoxin removal services, you can also make additional choices. Through our proprietary codon optimization software and our experienced scientific team, we guarantee the delivery of high-quality final products.

Basic Service Procedures

• Communicate about protein expression requirements.
• Sign contract and make prepayment.
• Carry out pilot study for protein expression.
• Feedback pilot study result and ship sample (if feasible).
• Bulk production quotation.
• Bulk production based on customer requirements.

Creative BioMart is always devote us to provide high-quality and satisfactory service to our customers, if you are interested in our services or have some question, please feel free to contact us or make online inquiry.

Online inquiry