Optogenetics is a technology that uses light to manipulate neural activities defined by genes. Its advantages include the accuracy of time and space. In optogenetic experiments, only neurons expressing optogenetic probes are controlled to activate or inhibit these neurons.
Time accuracy allows researchers to turn neurons on and off in milliseconds. This rapid time can closely mimic the firing rate of neurons in the brain. Spatial precision allows researchers to manipulate the activity of genetically defined populations of neurons, such as inhibitory neurons. This provides a causal relationship between the operation of genetically defined populations and the measured variables.
There are many technical R & D talents in the field of neuroscience in the technical team of Creative BioMart. Our Neuroscience Technology Platform is combined with cell culture, model biology R & D and optogenetics equipment platform to jointly achieve our optogenetics business.
Nerve cells were cultured using the media and supplements developed by Creative BioMart to provide the best conditions. We have cell culture biosafety cabinet, cell culture box, plastic products and consumables for nerve cell culture.
We have a wide range of nerve cell products, including mouse, rat and human neural primary and stem cells.
We have confocal microscope, two-photon microscope, high-throughput virtual tissue slicing system, ultra-high speed confocal microscope, super-resolution fluorescence microscope and living cell imaging system to support the visualization of target targets in living cells, fixed cells or tissues. We used optimized immunocytochemistry (ICC) and immunohistochemical reagents to achieve specific and reliable ICC / IHC staining.
Two photon microscopy is mainly used for deep imaging of brain sections, retinas, zebrafish, mice and rats.
Confocal microscopy is mainly used for multicolor high-resolution fluorescence imaging, large-scale 3D imaging and living cell imaging of fixed specimens.
High throughput virtual tissue slice system is mainly used for large field fluorescence imaging and large-scale two-dimensional imaging of fixed brain slices.
Viral gene delivery vector is an important tool in scientific research. They are widely used because of their low cost and long-term stable gene expression. The most commonly used systems are lentivirus and adeno-associated virus (AAV). The work of our facility is to insert light elements into nerve cells through the packaging and purification of viral gene delivery vectors, so that they can be used for optogenetic research.
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