Researchers have been committed to the study of neural circuits of different behaviors to explore their projection connections. To observe the corresponding behavior after regulating the activity of a certain kind of neurons. The methods of electrical stimulation and pharmacology may lead to inaccurate experimental results. Photogenetics technology has the characteristics of strong purpose, low injury, high temporal and spatial resolution and genetic specificity. In recent years, it has been widely used in the research of biological mechanism in the field of neuroscience.
Creative BioMart has mastered and developed a variety of optical switching systems for System Neuroscience. We have the ability to provide the construction services of cell lines, expression systems and model organisms.
Optogenetic technology combines optical and genetic technology, uses virus vector, introduces microbial opsin gene into the brain tissue of carrier animals, irradiates with light of different wavelengths and frequencies, and regulates the function of specific cell groups or specific neurons by stimulating light sensitive proteins, so as to control the behavior of animals.
The research involving neural circuit and brain function can not be carried out directly on human body, so animal model has become an important choice.
Animal behavior research
Photogenetics has a good prospect in the application of animal behavior, especially in the study of the causal relationship between specific types of neuronal activity paradigm and animal behavior changes.
Optogenetics technology makes an in-depth study on the neural circuits of animal communication behavior, fear memory behavior, reward memory behavior and anxiety like behavior. It can not only record the overall brain activity of living animals, but also record the activity performance of cells and molecules to study the activity of neural circuits. It is an important event to study the neural circuits of animal behavior, It promotes the progress of neural circuit research.
Establishment of animal model
At present, animal models that can summarize the important characteristics of mental diseases, such as fear memory, anxiety disorder, depression and so on, have been successfully established. At the same time, optogenetics is used to clarify the neural pathways related to many complex behaviors of mental diseases in rodent models.
Animal behavior and neural circuit research
In the animal communicative behavior test, the role of hypothalamic secretin/eating hormone in a specific situation can be clarified through optogenetic technology. Neural circuit is the bridge between nerve cells, molecular activities and the overall activities of the brain. Using optogenetic technology, the optical regulation of neurons and synapses with high time resolution and high accuracy is realized in animals, which provides a better solution for the study of neural circuits in animal behavior.
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