Application of Knock-in Model

• Simulate human genetic mechanism and explore pathogenic mechanism
• Tracer gene expression
• Lineage tracing was performed to trace the origin of cells
• Humanize mouse genes and accelerate drug research and development
• Molecular genetics tools were introduced into mouse models

Gene Knock in Models Include

• Conventional gene knock in
• Point mutation
• Conditional point mutation
• Humanization

Through CRISPR gene editing technology, it generally takes more than 8 months to construct a gene knock in mouse model. Through ES cell targeting technology, it generally takes more than 8 months to construct a gene knock in mouse model.

You can contact Creatice BioMart's technical consultant to design and customize your gene knock in mouse model for you.

Conventional Gene Knock-in

Foreign gene co-expression strategy

Exogenous gene substitution for endogenous gene expression strategy in mice (i.e. knock-in and knock-out).

Point Mutation

Point mutation (human pathogenic candidate point mutation) was introduced into the corresponding position of mouse homologous gene.

Conditional Point Mutation

By combining point mutation (human pathogenic candidate point mutation) with CRE loxP system and introducing it into the corresponding position of mouse homologous gene, tissue-specific point mutation can be realized.

Humanization

A humanized genetic engineering mouse model for disease, immunity, physiology, antibody drug screening and efficacy evaluation was constructed by replacing mouse endogenous genes with human homologous genes.

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