Strain for Rhythm Research
Strain Construction
The transgenic mice of this strain can be used for optogenetic research, and provide a useful tool for the induced light stimulation of glutamatergic neurons involved in rhythm generation and motor initiation. The channel rhodopsin-2 cDNA sequence of Chlamydomonas reinhardtii was modified to include codons optimized for mammalian expression and function acquisition sequence replacement. The optimized channelrhodopsin-2 sequence was fused with enhanced yellow fluorescent protein (EYFP) sequence. Transgenic mice expressed channelrhodopsin-2/EYFP fusion protein targeting the spinal cord and hindbrain motor region.
Under blue light, ChR2 activates YFP expressing cells and induces neuronal activity of glutamatergic populations in the spinal cord and hindbrain motor regions.
At present, Creative BioMart has developed a variety of mouse strains expressing Channelrhodopsin, halorhodopsin and Archaerhodopsin respectively, which facilities the application of optogenetic. We have complete animal maintenance facilities to ensure animal health and animal welfare.
Strain Details
Expressed Gene: Yellow Fluorescent Protein (YFP) from jellyfish, Channelrhodopsin from Chlamydomonas.
Expressed Site: These transgenic mice expressed channelrhodopsin-2/EYFP fusion protein targeting the spinal cord and hindbrain motor region.
Genotype: Inquiry
Strain Application
This mouse can be used to support research in many areas including
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Research Tools |
Biology Research |
- Genetics Research
- Tissue/Cell Markers: neurons
- Fluorescent Proteins
- Neurobiology Research
- cell marker
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- Optogenetic and Chemogenetic tools
- Channelrhodopsin expressing strains
- Fluorescent protein expression in neural tissue
- Channel and Transporter Defects
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Please note that
Creative BioMart has strict gene quality control and mutation genotyping procedures. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheet. Therefore, we cannot guarantee that the phenotype of the strain will meet all expectations.
Why Choose Us
- Creative BioMart has been upgrading and innovating existing technologies to ensure satisfactory delivery time and results.
- We provide cost-effective one-stop service, and the overall experimental process is transparent and verifiable.
- We provide customized services for each client and formulate experimental schemes based on customer requirements.
- We have an advanced technical team and experimental platform, and all technicians have been strictly trained and screened to ensure the most accurate experimental results.
- We strictly keep business secrets and never disclose customer information.
Creative BioMart is always devote us to provide high-quality and satisfactory service to our customers, if you are interested in our services or have some question, please feel free to contact us or make online inquiry.
