Caenorhabditis Elegans for Optogenetic Research

Caenorhabditis elegans is a compact neural circuit composed of 302 neurons, which plays an important role in the development and application of optogenetics. The application of optogenetic in Caenorhabditis elegans has greatly changed the experimental design, increased the accessibility of neural activities and accelerated the research of neural circuits by providing tools. Combining different methods, such as electrophysiology, expands the potential of optogenetics and other methods by improving the resolution of elucidation. In addition, the specially developed techniques combined with optogenetics, such as pattern lighting, provide a new tool for the study of neural function.

Now Creative BioMart can not only build C.elegans strains for specific optogenetic technology, but also be able to insert conventional optical elements into C.elegans genome through gene editing methods.

Reasons to Use Caenorhabditis elegans

Caenorhabditis elegans has been an important model organism for various biological research for about 40 years. Its rich advantages of scientific research such as short life cycle, transparent body and convenient genetic analysis have promoted various research fields, including genomics, cell biology, development, aging and neuroscience.

Transparent body. Optical manipulation requires the conveyance of specific light stimulus to target molecules.
Abundant promoters. Specific expression of opsins or genetically encoded indicators (GEIs) is a key technology in optogenetics.
The connectome has been produced. Fully annotated anatomical information for C. elegans, including a neural circuit map, is beneficial when planning effective experiments to study neural circuits using optogenetics.
Preserving high-order functions with a compact neural circuit. Caenorhabditis elegans retains simple neural circuits advanced functions, such as sensation, learning and memory stimulated by environment.

Available C. elegans Strain /Services at Creative BioMart

Services

Strains/ Strain Construction Services

C. elegans Strain Responds to Blue Light
C. elegans Strain for Neuromodulation Study
C. elegans for Tracking System
C. elegans for Calcium Imaging and Neural Manipulation

Other Services

C. elegans for In Vivo Toxicity Testing

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