Blue Light Rapid Response Strain, Cre Dependent

Strain Description

The mouse is fertile. When mating with mice expressing Cre recombinase, the expression of channelrhodopsin-2 (H134R) derived from Chlamydomonas reinhardtii and its fused enhanced yellow fluorescent protein can be initiated. The strain is designed to produce greater fixed photocurrent.

Bacterial opsin is a retinal binding protein that binds photosensitive domains and ion channels or pumps. It provides light dependent ion transport, membrane potential change and sensory function for bacteria. This ChR2(H134R) acts as a blue light driven cation channel, depolarizing cells and causing action potentials. Irradiation of cells expressing ChR2(H134R) with blue light (450-490 nm) resulted in rapid and reversible stimulation of action potential discharge activity in these cells.

At present, Creative BioMart has developed a variety of mouse strains expressing Channelrhodopsin, halorhodopsin and Archaerhodopsin respectively, which facilities the application of optogenetic. We have complete animal maintenance facilities to ensure animal health and animal welfare.

Strain Details

Expressed Gene: Channelrhodopsin, enhanced yellow fluorescent protein (EYFP)

Genotype: Inquiry

Strain Application

This mouse can be used to support research in many areas including

Neurobiology Research	Genetics Research	Developmental Biology Research	Other
Optogenetic and Chemogenetic tools Channelrhodopsin expressing strains Cre-dependent optogenetic tools Fluorescent protein expression in neural tissue	Tissue/Cell Markers Mutagenesis and Transgenesis Tissue/Cell Markers: cell marker for bone marrow transplantation Tissue/Cell Markers: transplantation marker for embryonic and adult tissue Tissue/Cell Markers: Cre-lox System Mutagenesis and Transgenesis: Cre-lox System	transplantation marker for embryonic and adult tissue Cre-lox System	Fluorescent Proteins Diabetes and Obesity Research

Please note that

Creative BioMart has strict gene quality control and mutation genotyping procedures. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheet. Therefore, we cannot guarantee that the phenotype of the strain will meet all expectations.

Why Choose Us

Creative BioMart has been upgrading and innovating existing technologies to ensure satisfactory delivery time and results.
We provide cost-effective one-stop service, and the overall experimental process is transparent and verifiable.
We provide customized services for each client and formulate experimental schemes based on customer requirements.
We have an advanced technical team and experimental platform, and all technicians have been strictly trained and screened to ensure the most accurate experimental results.
We strictly keep business secrets and never disclose customer information.

Creative BioMart is always devote us to provide high-quality and satisfactory service to our customers, if you are interested in our services or have some question, please feel free to contact us or make online inquiry.