The mouse is fertile. When mating with mice expressing Cre recombinase, the expression of channelrhodopsin-2 (H134R) derived from Chlamydomonas reinhardtii and its fused enhanced yellow fluorescent protein can be initiated. The strain is designed to produce greater fixed photocurrent.
Bacterial opsin is a retinal binding protein that binds photosensitive domains and ion channels or pumps. It provides light dependent ion transport, membrane potential change and sensory function for bacteria. This ChR2(H134R) acts as a blue light driven cation channel, depolarizing cells and causing action potentials. Irradiation of cells expressing ChR2(H134R) with blue light (450-490 nm) resulted in rapid and reversible stimulation of action potential discharge activity in these cells.
At present, Creative BioMart has developed a variety of mouse strains expressing Channelrhodopsin, halorhodopsin and Archaerhodopsin respectively, which facilities the application of optogenetic. We have complete animal maintenance facilities to ensure animal health and animal welfare.
Expressed Gene: Channelrhodopsin, enhanced yellow fluorescent protein (EYFP)
Genotype: Inquiry
This mouse can be used to support research in many areas including
| Neurobiology Research | Genetics Research | Developmental Biology Research | Other |
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Creative BioMart has strict gene quality control and mutation genotyping procedures. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheet. Therefore, we cannot guarantee that the phenotype of the strain will meet all expectations.
Creative BioMart is always devote us to provide high-quality and satisfactory service to our customers, if you are interested in our services or have some question, please feel free to contact us or make online inquiry.
