As an unparalleled global supplier of life science services and products, Creative BioMart provides comprehensive services for the generation of stable cell lines for biological production. Our services cover all steps of stable cell line generation, from initial gene synthesis to the final delivery of high-yield cell clones.
Drosophila Schneider 2 (S2) cells have long been considered as a powerful cell culture model to study the potential mechanism of controlling cell division. The study of these very dynamic cellular processes needs to develop from established genetic methods to methods with high spatial and temporal control to disrupt protein function. The progress of optogenetic tools for rapidly regulating protein activity with light provides unprecedented spatio-temporal control for dynamic cellular processes, and may bring fruitful results to cell biologists.
Creative BioMart inserts lariat module into Drosophila cells to provide customers with stable Drosophila S2 cell construction services that can be used for optogenetic research, so as to achieve the purpose of interfering with protein function and high temporal and spatial control. The response of the S2 cell line to light depends on the rapid light dependent heterodimerization between cryptochrome 2 (CRY2) and cryptochrome interacting bHLH 1 (cib1) to form large protein clusters. CRY2 and cib1 form homologous oligomers and heterodimers within seconds after blue light exposure.
Drosophila S2 cells added with optogenetics module can be used to study protein function and interaction. Drosophila lariat allows light controlled clustering of proteins at the single cell level, which can be used to interfere with protein localization and function in S2 cells. This is particularly useful for proteins involving multiple processes, whose consumption leads to pleiotropic phenotypes.
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